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Nanoparticles are microscopic particles that measure less than 100 nanometres. A nanometre is one thousand-millionth of a metre ( 0.000000001 m). Scientists have developed nanoparticles that can target cancer cells. When cancer cells take up ordinary nanoparticles, they often enclose them in small compartments called endosomes. This prevents the drug molecules from reaching their target. Researchers from Ohio State University in America have developed a "nanobomb" which can explode the endosome compartments and release the drug molecules. Click here to read a news report about the "nanobomb" in Science Daily. At this stage the nanobomb has been tested in animals only, not humans.
Paul Edwards posted a topic in Articles on other sitesOn 20 March 2015, The New Prostate Cancer Infolink collaborated with the CureTalk network to coordinate a discussion with the well-known medical oncologist Maha Hussain, MD, of the University of Michigan on “Current trends in the management of advanced and late stage prostate cancer.” You can access a full audio recording of this discussion and a complete transcript by clicking on this link.
Charles (Chuck) Maack posted a topic in New agentsStill in the early stages of study, but appears promising in the future for reining in/slowing prostate cancer development. HIV drug blocks bone metastases in prostate cancer http://tinyurl.com/ppju6bz “Although prostate cancer can be successfully treated in many men, when the disease metastasises to the bone, it is eventually lethal. The receptor CCR5, targeted by HIV drugs, is also key in driving prostate cancer metastases, suggesting that blocking this molecule could slow prostate cancer spread.” “…maraviroc dramatically reduced the overall metastatic load by 60 percent in the bone, brain and other organs” Maraviroc: Internationally known as Selzentry This medication is an anti-retroviral agent, prescribed for HIV infection (CCR5-tropic HIV-1 detectable). It works by blocking the virus from entering cells. Contraindicated in patients with severe kidney problems, who are taking St. John's Wort, and hypersensitivity. Read more: Maraviroc (Selzentry) Drug Information - Indications, Dosage, Side Effects and Precautions | Medindia http://www.medindia.net/doctors/drug_information/maraviroc.htm#ixzz3KlBY2OrC Chuck
Paul Edwards posted a topic in Articles on other sitesThis post in the New Prostate Cancer Infolink suggests that "the failure of this drug to demonstrate significant efficacy in either one of two Phase III trials for the treatment of metastatic, castration-resistant prostate cancer has surely ended any attempt to develop this drug for the treatment of prostate cancer."