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Admin posted a topic in Any suggestions?Chalkie asks: I am now having to choose between Zytiga and Xtandi. Is there a forum for this? Any suggestions? Jim Marshall (not a doctor) said ... A recent trial for men with metastatic prostate cancer who were no longer responding to ADT alone (mCRPC) showed similar outcomes on both drugs. So, it appears your doctor could recommend either, unless they are worried about how a particular side effect may affect you personally: If you have a health condition that could be made worse by possible seizure or fatigue, your doctor may steer away from Xtandi. If you have a health condition that could be made worse by possible by increased blood pressure, low potassium, or increased liver enzymes, your doctor may steer away from Zytiga. ... end Jim A link to an article on this can be found here: Abiraterone and Enzalutamide equivalent as first-line therapy in metastatic hormone therapy- resistant prostate cancer