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  1. As mentioned in today's teleconference, I am a consumer representative on a research project being conducted at the Garvan Institute of Medical Research in Sydney into better management of active surveillance using epigenetics. Epigenetics is about whether genes are turned on or off, rather than whether they are there or not (genetics). One of the major epigenetic mechanisms is methylation, the addition of methyl groups to the DNA strands. If they are added near individual genes, they can turn off the activity of that gene. Researchers are also doing an ep
  2. A mice study not tried on humans "By introducing a particular strain of bacteria into the digestive tracts of mice with melanoma, researchers at the University of Chicago were able to boost the ability of the animal's immune systems to attack tumor cells. The gains were comparable to treatment with anti-cancer drugs known as checkpoint inhibitors, such as anti-PD-L1 antibodies." Click on this link to read a report about this research. Click on this link to read a recent article from Memorial Sloan Kettering Cancer Centre about microorganisms in the gut.
  3. Tonight's Catalyst program on ABC TV was about a group of cancer patients who are experiencing extraordinary benefits from prescribed targeted exercise programs during chemotherapy. The program will be repeated on Friday 13 May 2016 at 10.30am. Alternatively you can watch it on iview until 19 December 2016.
  4. Paul Edwards

    The tumour trail in blood

    Click on this link for an interesting article from the journal, Nature, about how liquid biopsies can detect cancer signs from a blood sample, without the need for invasive procedures. But further work is needed before they can become reliable diagnostic tools.
  5. Sam Poley's father had aggressive and advanced prostate cancer. About a year ago Sam started a crowdfunding campaign to raise at least $1 million to fund a Phase II clinical trial to investigate the feasibility of using an FDA-approved and generally well-tolerated drug called disulfiram in the treatment of castration-resistant prostate cancer. Prostate Cancer needs copper—in fact, it’s a glutton for copper and will consume all it can get. This clinical trial will be designed to exploit that as a weakness Unfortunately Sam's dad has died but the appeal has raised $460,000 so far. Th
  6. Perhaps the "whack-a-mole" approach may not be the best long term strategy. Click on this link to read an interesting article in Scientific American about how scientists are piecing together a more precise picture of how cancer evolves, revealing the roots of resistance and, in some cases, finding out how it might be overcome.
  7. PSMA The big thing in Australian prostate cancer research in 2015 was a little wiggly shape that sits on the wall of a prostate cell - PSMA. In normal prostate cells, PSMA is mostly on the inside of the cell wall. In prostate cancer cells, PSMA moves to the outside of the cell wall. So, if you want to find prostate cancer cells - look for PSMA. Researchers have found a key that locks onto PSMA when it finds it. On the free end of this key they can attach lots of things. PSMA scans One type of thing that is attached to the free end of the key is a thing that will show up o
  8. Click on this link to read the article in Scientific American.
  9. There is an extensive list of research articles about the benefits of exercise at the Medafit website, both for cancer generally and, more specifically, for prostate cancer. To read these articles, click on this link.
  10. Paul Edwards

    Who's in your "Dream Team"?

    If you could pick "The Best of the Best" or "The All-Time Greats", who would you pick in your Dream Team, a team of champions? Whether it's cricket, rugby, AFL, soccer or basketball, everyone has a wish list for their Dream Team. A few years ago some cancer organisations got together and said "If we could pick a Dream Team of Cancer Researchers, who would be in it? Who are the Best of the Best? Rather than having these leading scientists from different organisations competing for research funding, what would happen if we had the best researchers from the leading cancer centres workin
  11. The University of South Australia are looking for men who are within 1 year of receiving a prostate cancer diagnosis, and their partners, to volunteer in a study which will explore experiences of prostate cancer in everyday life. The study involves a recorded telephone interview of about 30 minutes. Movember is funding the study. Professor Suzanne Chambers from Griffith University is one of the Study Investigators. If you are interested in participating, please call Katrina Stamp on (08) 8128 4092 or email her at Katrina.stamp@sahmri.com [To achieve better outcomes for
  12. Paul Edwards

    ABC Jim

    Yesterday the ABC reported the results of some new prostate cancer research funded by Movember and the Prostate Cancer Foundation of Australia. They interviewed Jim Marshall as part of the report. Later in the day when Jim was out and about, someone asked him "Are YOU Jim Marshall? - I recognise your voice!" If you missed Jim on the radio, click here to listen to the story or to read the transcript. Well done, Jim!!
  13. The following item by Dr Prue Cormie, a Senior Research Fellow at Edith Cowan University Perth, was first broadcast on the ABC on the Science Show on Saturday 31 May 2014. We are grateful to the ABC and Dr Cormie for permission to publish a transcript. Men think about sex a lot. On average every 45 minutes, which is more often than they think about food or sleep. So it's not surprising that sexual dysfunction is the most frequently identified issue of importance among prostate cancer survivors. Significant reductions in sexual well-being occur in up to 90% of men with prostate cancer.
  14. I just happened to catch a segment on the ABC Science Show about A New Approach in Drug Design For Treating Prostate Cancer. Click on this link to listen to the segment or to read a transcript I was impressed with the way that the young researcher spoke about her work and why research is needed for prostate cancer. She spoke in simple easy-to-understand language.
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