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  1. Hi guys Is anyone enrolled in the Profound trial or have any knowledge of this? The official purpose of the trial is: The purpose of this study is to evaluate the efficacy and safety of olaparib versus enzalutamide or abiraterone acetate in subjects with metastatic castration-resistant prostate cancer who have failed prior treatment with a new hormonal agent and have homologous recombination repair gene mutations This trial has been enrolling in Australia over the last 6 months or so. I have germline BRCA2 mutation which has probably caused my mCRPC disease. I have been through my options with enzalutamide and abiraterone and have had Docetaxel. Currently looking at commencing a platinum based chemotherapy treatment using Carboplatin, normally used in Ovarian cancer. Any thoughts/experiences around Profound and/or the BRCA mutation and treatment experiences would be very welcome. Thanks and best wishes to you all Martin
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