Jump to content


Popular Content

Showing most liked content since 10/19/2017 in all areas

  1. 1 point
    It appears the doctors have started your dad on the standard form of Adrogen Deprivation Therapy, aka AHT, aka Hormone therapy, HT, and so far the activity of the cancer has been much reduced and It appears the doctors plan to give him continuing monthly injections of Goserilin to suppress his internal production of testosterone. I have had the same treatment since 2010. I presently alive and very well even with a large number of small mets in bones. But it seems maybe you dad was diagnosed when Psa very high, and he may not have had yearly Psa tests. His Psa may have been only 5.0 at 4 years ago if the doubling time was 6 months. Before my diagnosis my Psa had a doubling time longer than 2 years, but after Psa hit 5, and diagnosis, doubling time reduced to 6months, and I had an inoperable Gleason 9 grade tumor which had probably already spread so that the initial treatment with ADT and then radiation didn't work on the main Pca site of prostate gland, and even if it had worked, the many metastasis sites were not radiated and I was not free of the disease even though Psa went from 8.0 at initial attempted operation to 0.08 at 18 mths later. When I paused the ADT in 2012 for 6 mths, Psa went from 0.08 to 8.0, and I re-started ADT and got Psa below 0.25. But Psa slowly crept higher, and I knew the Pca would be a threat as long as I lived, and all I could do is slow its progress down. I knew I could never get permanent remission, ie, a cure, such a thing is presently so extremely rare it is thought to be virtually impossible, and I have ZERO hope of ever getting a cure. I don't know of anyone who has begun Docetaxel chemo therapy before having spent years on ADT. You may like to hit the cancer hard and soon, get your dad well, but you may find that there's no evidence to indicate early chemo therapy would work. You say your dad is frail and may not withstand the side effects of chemo. Perhaps this is true. But we don't know how old your dad is, and if you were born in 1941, you are 76, and dad might be 96, and I'd agree he may not like side effects of chemo. The ADT can only slow down the Pca; it puts the Pca cells into a sort of coma, they don't die, but remain dormant. But your dad's adrenal gland makes a very small amount of testosterone and its not suppressed by normal ADT so the Pca does get s tiny amount of testo so it grows very slowly until it changes its chemical structure to enable its self to grow without testo. So normal ADT does not work for longer than about 10years, but some get only 2 years before the ADT becomes ineffective. I've had 6.5 years on normal ADT, but am now on much stronger ADT drug Zytiga, and I might get two more years of Pca suppression. Then the Pca will mutate to grow and everything the doctors do will not work. Chemo and systemic radiation like Lu177 may only hold it down for 2 years. I could easily be dead in 5 years. But I'm only 70, and apart from Pca, I am lucky to be fabulously healthy; I cycle 250km+ a week, and some blokes 50 struggle to keep up. But by 80 or 90 I will take my turn to become frail and unable to respond to treatment. I'd like to delay the inevitable, but it is of course impossible, so I hope there's good palliative care when I need it, or some other means of quitting if I just don't want to live any more. I never got around to having my own family so I am alone, and I go to a place of care away from home I know I'll be amoung the 50% who never get a visit during a full year, but that's how it is now, and I am used to being alone and not grumbling about it. Care for aged ppl in Australia isn't something we can be very proud of. I'm involved with enough ppl to be happy. Having Pca is no worse than having some other long term chronic disease, and if a bus runs over me tomorrow, so be it, but my care of myself has been so good that I may well spend a few years away from home, which is just a damn house, and I'll agree with the move out and end game when doctors can see what is going to happen. I have seen a number of people transition from home to care, and they passed without too much prolonged agony. There's few ppl here who can talk about their future. I can, and I know I have a short future; it is being real, and I've never needed any help dealing with reality. But if you need help, then seek it, and talk to those who may ease your disquiet. We all wish we could provide a better solution to the pains of being alive, but we can only share stories of how we extended life to the maximum, and all of us suffer when a loved relative is in trouble. I watched my dad fade at 60, from melanoma, and saw my mum live happily to 98, and she was comfortable as possible but much of how my sisters and I remember her vanished well before 98, and she wasn't fully aware when nature took its course. One sister is already gone, and she died bravely at 60 from ovarian ca and day before she was chirpy and happy at the care place, but knew she had 2 weeks max, and she overdosed on the morphine drip to avoid the 2 weeks, unable to eat again. It may be the same for me, those around me will know when its time and give me a little help. Its going on all the time and may become officially OK in Victoria soon. But between now and my end, I want to live, and maybe I'll cycle another 50,000km, and not be completely alone. If Pca pushes me off the bike and off Planet Earth, then so be it. It may be very good luck for your father to be included in next Lu177 trials. Word has spread about Lu177, and other special new RT, so demand would be huge from hundreds if not thousands of men and their families wanting to keep life going. It seems the qualifier to be included in trial is to have progressed to having chemo, and the LU177 is not going to be used before other things like ADT has begun to fail. I've heard there's a clinic in Perth and with Sydney branch giving Lu177 infusions at $10,000 each, and maybe a man needs 4 infusions. Your dad needs referrel to them by a doctor and there would be a conference by skype to Perth clinic which isn't cheap but you need to remember that whatever treatment you want for your dad may not be deemed to be worth trying. The doctors have already seen hundreds of similar cases. And the doctors all hope that some better treatment will become available soon but "soon" may be 10 years away. There is some hope for immune therapy which is presently being heavily researched at Sloan Kettering hospital in US and there may be good improvements for the targeted Lu177 and other similar things but I am not holding my breath. Patrick Turner.
  2. 1 point
    Hi Maffey, I wont pretend that survival has been easy or a breeze for me or my wife - but necessity is a great motivator. We have made every attempt to live life as normally as can be done when one has advanced metastatic prostate cancer.I kept working until I was 70 and I am always active and busy there is never enough hours in the day. I am involved in a local Prostate Cancer support group, this group, and I usually finish up having one or two visits to hospital each week as I have other medical problems aside from PCa. In addition to my scholarly interest in prostate cancer research and treatment, I am heavily involved in a range community projects. Whilst I participated in Deakin University Impact exercise trials for a year, and keep reasonably active, I have never gone overboard in terms of any long term continuous or arduous exercise program and my wife keeps me on the straight and narrow with a very normal but healthy diet. Although of recent times mobility is becoming more of a problem. However, I have for many years taken charge of my own health and accepted the fact that I am responsible for making the decisions relating to my cancer treatment. I spend a lot more time than most - researching the treatment I am currently receiving and other possible main stream treatments and trials that might be beneficial for me both now and in the future. Cheers Maffey, Barree
  3. 1 point
    Hi Maffy, Where there is life there is hope. Life and Prostate Cancer treatments are I feel very akin to the way we view life itself. It's very much like the glass of water when the water is at mid level - is it half full or half empty. The optimist sees it as being half full - the pessimist as half empty. Getting on for 20 years ago now I was diagnosed with PCa and told to get my affairs in order as I had about 6 mths to live. A prognosis I refused to accept. No where on my body have I ever found a use by date. Since then I have been on various clinical trials. I have applied for every clinical trial I felt would extend my life, including the first Lutetium 177 trial. The initial Lutetium177 trial for me concluded back July 2016. At times it hasn't been easy but I am still alive and kicking goals. I cant agree there is no hope.I am optimistic and full of hope about the range of new Prostate Cancer treatments and drugs that continue to appear on a regular basis and I keep looking for the next treatment or trial that looks as if it will give me some more time - who knows what will come along in the near future. Cheers, Barree